Bachelor of Science (Hons), Chemistry with Molecular Biology and Biochemistry @
A highly motivated and innovative medicinal chemist and drug discovery leader with 14+ years experience in both small and large pharma (Vertex, Pfizer & FORMA Therapeutics) across multiple therapeutic areas (oncology, respiratory, inflammation, & pain). Drug discovery experience spans lead generation through to late stage lead optimization and candidate identification, against enzyme targets (caspases, kinases, metabolic enzymes),
A highly motivated and innovative medicinal chemist and drug discovery leader with 14+ years experience in both small and large pharma (Vertex, Pfizer & FORMA Therapeutics) across multiple therapeutic areas (oncology, respiratory, inflammation, & pain). Drug discovery experience spans lead generation through to late stage lead optimization and candidate identification, against enzyme targets (caspases, kinases, metabolic enzymes), PPIs, NHRs and ion channels. An accomplished and confident leader of multi-disciplinary project teams that deliver impact (5 development candidates & numerous lead series that answer key biological questions). This is documented by a consistent publication (papers, reviews & book chapters), patent, and external presentation track record. Developed a broad and comprehensive awareness across all drug discovery disciplines and in particular a unique experience as a DMPK project lead in a one year secondment in Pfizer’s DMPK group. A supervisor, and advisor to associate and experienced PhD level scientists who aims to guide and grow people to be the best they can be. Thrives at recruiting, building and motivating teams in scientifically driven and goal orientated environments. Ultimately driven by scientific curiosity, a hunger to learn, and a desire to discover new medicines for unmet medical need.
Director of Medicinal Chemistry @ Director of Medicinal Chemistry responsible for the leadership of people and projects across novel oncology target space within areas such as tumor metabolism and epigenetics. Responsible for leading and guiding project teams to identify high quality lead compounds and series from FORMA's high throughput screening engine. Forms strong collaborative partnerships with biology, and other partner lines, to develop lead compounds with appropriate properties to answer key biological questions and in turn to deliver candidate molecules to enter clinical development. A member of the chemistry leadership team that recruits, builds and directs the chemistry discipline within FORMA. A supervisor and mentor of both associate and experienced PhD level scientists that aims to guide and grow people to be the best they can be. Involved in leading and directing science both internally, at CROs, as well as leading scientific collaborations with FORMA’s partners. From August 2011 to Present (4 years 1 month) watertown, ma, usaSenior Principal Scientist @ Drug design leader responsible for directing the medicinal chemistry strategy on multiple projects, and co-leader of multidisciplinary project teams. Invented, developed and progressed high quality lead series and clinical candidates in respiratory (inhaled p38 kinase, oral PI3 kinase, inhaled glucocorticoid agonists) and pain (Nav1.7, TRPV1) therapeutics areas. Supervised and directed both internal and CRO based synthetic chemistry teams, involving PhD and associate level chemists. Delivered 5 clinical candidates (2 currently in clinical trials), inventor on 7 patents, lead author on 5 peer reviewed journal articles, 4 book chapters and 5 oral presentations at international conferences. An internally recognized expert in the understanding and application of DMPK principles in drug design which was developed through a one year secondment in Pfizer's DMPK group. Developed a unique experience in metabolic and transporter mediated clearance, as well as application of PKPD relationships, and human clearance and dose predictions from preclinical pharmacokinetics. From July 2004 to July 2011 (7 years 1 month) sandwich, united kingdomInvestigator @ Individual contributor medicinal chemist responsible for the design, synthesis and purification of novel compounds to inhibit caspase enzymes for sepsis, and kinase inhibitors (AKT, PDK) for oncology. Inventor on 1 patent. From July 2001 to June 2004 (3 years) oxford, united kingdomPostdoctoral Research Fellow @ Responsible for development of the late stage strategy, synthetic route design and synthesis of advanced intermediates towards the total synthesis of the complex natural product Phorboxazole A in the laboratory of Professor Gerry Pattenden. From August 1999 to July 2001 (2 years) Nottingham, United Kingdom
PhD, Synthetic Organic Chemistry @ Flinders University of South Australia From 1996 to 1999 Bachelor of Science (Hons), Chemistry with Molecular Biology and Biochemistry, First Class @ Flinders University of South Australia From 1992 to 1995 David Millan is skilled in: Medicinal Chemistry, Organic Chemistry, DMPK, Drug Design, Drug Discovery, Synthetic Organic..., Organic Synthesis, Cancer Research, Respiratory Therapy, Protein Kinases, Lead Generation, Lead Optimisation, Drug Safety, Drug Delivery, Drug Metabolism, Pharmaceutical Industry, Pharmacokinetics, Pharmaceutical Sciences, Biotechnology, in Vitro Toxicology, Leadership, Team Leadership, Mentoring, Science, Written & Oral..., Leading Meetings, Project Management, Communication, Lead Change, Clinical Trials, ADME
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