Sreshtha Nandy

Real-World Drug Discovery Expert

Associate Professor at Center for Drug Discovery at Northeastern University
(Jan 2023 – Present)

Pharmaceutical Sciences at Northeastern | Research Assistant in the Plant Lab

• Assist pharmacists in accurately dispensing prescription medications following established procedures and protocols.
• Conduct prescription order entry and input prescription data into the computer system with a high level of accuracy.
• Maintain a thorough understandi...

Pharmaceutics | Drug Delivery | CNS Drug Delivery & Design | Drug Discovery | Nanomedicine | MS Candidate at Northeastern

α4β2 Positive Allosteric Modulators Project

- Led the synthesis of dFBr analogs designed to modulate α4β2 nicotinic acetylcholine receptors (nAChRs), a critical target in central nervous system (CNS) drug discovery.

- Designed and executed key synthetic steps, including ...

Behavioral Neuroscience Student at Northeastern University & Undergraduate Research Assistant at the Booth Lab

- Maintain mammalian cell culture and conduct transfection experiments to support receptor-based pharmacology studies
- Perform functional assays on serotonin receptors to evaluate pharmacological activity of novel ligands as part of a neuropsychiatric drug discovery pipeline
...

B.S. Pharmaceutical Sciences Student at Northeastern University

As an undergraduate researcher at the Logothetis/Plant lab, my work involves conducting TEVC experiments to investigate the electrophysiological properties of voltage-gated ion channels in oocytes, enhancing data accuracy across substance trials, including potassium and barium...

PhD Biochemist / Protein Chemistry & Drug Discovery / Computational Modeling

- Characterized >100 compounds across FAAH, ABHD6, and MGL enzyme assays, generating IC50 values to support dual-inhibitor SARs
- Built and validated ABHD6 models, retrospectively docked 78 inhibitors, and identified ligand-lid domain interactions driving potency
- Engineered ...