PhoenixBio Group

PhoenixBio Group established its proprietary chimeric mouse model, PXB-Mouse®, with a highly humanized liver through years of research and development. With the addition of fresh, isolated human hepatocytes, PXB-cells®, the applications of our products and study services is as wide-ranging as our clients’ research goals. PXB-Mouse®’s cDNA-uPA/SCID background makes for a robust, consistent model that maintains up to 95% stable human hepatocyte engraftment. The reconstituted humanized liver features structural and biological characteristics commonly observed in normal human livers. The model has proven to be a world-wide gold standard for Hepatitis B (HBV) and Hepatitis C (HCV) research, but usage is expanding in the fields of:. drug metabolism and pharmacokinetics,· hepatic toxicity,· oligonucleotide and genetic medicine,· other human liver-related research fields.PXB-cells® are approximately 95% pure human hepatocytes freshly isolated from a PXB-Mouse®. They feature long-term stability of up to 40 days, and allow for consistent supply from the same donor. One unique feature of PXB-cells® and PXB-Mice® is the ability to directly compare in vitro and in vitro data from the same human donor. With over 200 scientific publications to its credit, the PXB-Mouse® is the world’s most widely used chimeric mouse model with a humanized liver. A high replacement index, lifespan of up to 2 years, and no secondary drug to maintain mouse liver injury means that your data can translate better to humans than ever before.Please visit our website at http://phoenixbio.co.jp/en/ to learn more about our model and inquire about our offered products and services.