Domenico Larcinese's Email

- Graduated with honors in Biology at University of Naples in 1980. - Two year experience in the Italian Army, as Lieutenant in the Corp of Parachutists - Div. Folgore. - 10 year experience in Market Access arena in Italy, including Pricing & Reimbursement - 5 year experience in Market Access in Europe (27 markets) • 1/2014 till present – Director Payer Insights an Access – Pfizer Biosimilars, Anti-Infectives, Anti-Fungals. Responsibility: 27 Markets in Europe. Position based in Rome • 2/2011 12/2013 - Director Market Access - Inflammation - Responsibility: 16 EU Countries • 7/2010 - 2/2011 - Director Market Access - Endocrine Franchise – Responsibility: 16 EU countries • 3/2010 - 7/2010 - Sr. Manager Pricing, Reimbursement and HTA (Italy). Responsibility: P&R negotiations, Registration dossiers, Market Access tools, HTA evaluations • 2006-2009 -Sr. Mgr Health Outcome & Pricing (Italy). Responsibility. Pricing & Reimbursement negotiations with National and Regional HC Authorities and HO dossiers • 2001-2006 - Public Affair and Sr. Mgr Enbrel Market Access (Italy). Responsibility: Development of Regional agreements and Market Access tools for biologic therapies and • 2000-2001 - National Sales Mgr Vaccines. Sales Force and Key Account management. Wyeth Italy • 1999-2000 - National Account Mgr. Management of Wyeth national KAM team. Hospital Payers and Public Tenders management Technical Skills: Knowledge of the Pricing & Reimbursement environment and key access drivers in Europe. Development of complex P&R negotiations with National and Regional Authorities in Italy, development of stakeholder plans, reimbursement dossiers for new drugs, innovative contracting agreements (oncologicals), Biosimilars, Health Outcome dossiers, Budget Impact Models, HTA

Director Payer Insights & Access - Biosimilars, Anti-Infectives, Anti-Fungals - EUROPE @ • Market Access responsibility for the following Pfizer portfolio: Anti-Infectives, Anti- Fungals, Biosimilars and other Established Hospital products • Peri/post LOE Access strategy implementation for the Anti-Infectives, Anti-Fungals franchise • Access tools identification for the assigned product portfolio, including the upcoming biosimilars From January 2014 to Present (2 years) Market Access Director - Europe @ • Market Access responsability for Enbrel and the Inflammation franchise for Europe • Value Platform implementation through strategic and operative tools. • Price optimization • Innovative Commercial Strategies • Biosimilars From February 2011 to Present (4 years 11 months) Market Access Director - Endocrine - Europe @ • Global Market Access responsability for the the Endocrine franchise • Global Value Platform implementation through strategic and operative tools. • Price optimization/protection From August 2010 to February 2011 (7 months) Pricing, Reimbursement and HTA Sr Manager @ - Pricing and Reimbursement for new drug applications in Italy. - Market Access (National/Regional Authorities). - Pricing & Reimbursement dossiers. - Health Outcome & budget impact models for the Health Care System. - HTA dossiers From March 2010 to August 2010 (6 months) Health Outcome & Pricing Sr Mgr @ • Price negotiation with Regulatory Authority for new drug applications in Italy. • Market Access (National/Regional Authorities). • Pricing & Reimbursement dossiers. • Health Outcome & budget impact models for the Health Care System. From 2006 to March 2010 (4 years) Market Access Sr Mgr @ • Market Access of Wyeth key products at Regional level • Health Outcome dossiers • Budget impact models From 2005 to 2006 (1 year) Regional Public Affairs Sr Mgr @ • Strengthen Company Image and reputation at regional level • Payers and regional authority management • Budget impact evaluation according to the National/Regional cost containment measures • Regional projects From 2001 to 2004 (3 years) Vaccine National Sales Mgr @ • First Wyeth vaccine launch (Prevenar) • Sales force and key account management From 2000 to 2001 (1 year) National Account Mgr @ Managing contract agreeements and tenders with key Customers through a specialized team of high skilled managers From 1999 to 2000 (1 year)

Biology, Mononuclear phagocytes in the Central Nervous System @ Università degli Studi di Napoli 'Federico II' From 1976 to 1980 Latin & Greek @ Liceo Ginnasio Antonio Genovesi - Naples From 1970 to 1974 Domenico Larcinese is skilled in: Pricing and Reimbursement negotiation, Stakeholder Management, Market Access, Vaccines, Pricing, Life Sciences, Negotiation, Healthcare, Oncology, Lifesciences, Sales Effectiveness, HTA, Global Marketing, Pharmaceutical Industry, Product Launch