Postdoctoral Fellow- Energy Balance and Cancer Prevention @ The University of Texas Austin
Texas A&M University
I accepted a position as Sample Bank Manager at Luminex Corporation in March 2013. I was formerly a Postdoctoral Fellow in the Department of Nutritional Sciences at The University of Texas Austin beginning July 2008. My topic of study was the effect of energy balance modulation (via calorie restriction or pharmaceutical intervention) on breast cancer prevention, risk,
I accepted a position as Sample Bank Manager at Luminex Corporation in March 2013. I was formerly a Postdoctoral Fellow in the Department of Nutritional Sciences at The University of Texas Austin beginning July 2008. My topic of study was the effect of energy balance modulation (via calorie restriction or pharmaceutical intervention) on breast cancer prevention, risk, and prognosis. I previously conducted cancer biology research in the Department of Pathology at M.D. Anderson Cancer Center. My research focused on elucidating the role of various proteins in brain tumor progression, specifically for gliomas. My diverse research background has also included protein chemistry utilizing mass spectrometry technology at Texas A&M University, the mechanism of human immunology at Memorial Sloan-Kettering Cancer Center, and the mechanism of HIV viral packaging at M.D. Anderson Cancer Center Science Park. My research has resulted in 17 peer-reviewed journal articles, one book chapter, two journal cover images, and 32 conference presentations. I was fully funded for the duration of her academic career, currently holding grants from the Keck Foundation and the Department of Defense. I received my PhD from the University of Texas Health Science Center Houston in 2007, and my BS from Texas A&M University in 2003.
Senior Manager, Sample Bank @ • Pioneered the creation and management of the bio-specimen bank at Luminex Corporation in the Department of Systems Integration under the direction of the Global Commercialization team for the purposes of customer validation and R&D sample acquisition.
• Catalog and house thousands of clinical and contrived samples in our biobank. These samples include virus, parasitic and bacterial isolates for all our multi-plex and Sample-to-Answer assays.
• Experience with Document Control, Material Transfer Agreements, IRB protocols, CDC and USDA import/transport permits, FDA submissions for instruments/assays, and SalesForce.
• Spearheading Global Control Strategy which is a collaboration effort with commercial control vendors to develop Luminex validated control panels available for world-wide distribution. From March 2013 to Present (2 years 10 months) Austin, Texas AreaPostdoctoral Fellow- Energy Balance and Cancer Prevention @ • Design and implement specifically formulated dietary regimens for pre-clinical animal trials (calorie-restriction, Atkins, low-carbohydrate, nutraceutical enriched)
• Determined the effects of energy balance modulation on epithelial-to-mesenchymal transition and autophagy in clinically relevant murine models of claudin-low, basal-like, and HER2/neu positive breast cancer
• Examined the effects of targeting the Akt/mTOR pathway via pharmaceutical intervention to mimic calorie restriction in mammary cancer prevention
• Utilized Luminex-based western blotting and serum protein/cytokine analysis, ELISA for serum protein levels, flow cytometry for stem cell population and cell cycle analysis, invasion/migration chambers, immunofluorescence and immunohistochemistry for tumor proteins, in vivo techniques (tumor injections, drug delivery, surgeries, necropsy, cardiac puncture), and statistical analysis From July 2008 to March 2013 (4 years 9 months) Postdoctoral Fellow- NeuroOncology @ • Published translational research describing the role of integrin binding and NFκB signaling in IGFBP2-driven glioma progression in vivo and in human tumor samples
• Determined the role of Ink4a/Arf deletion, a common gene locus lost in human patients, in glioma progression in vitro and in preclinical models of human brain tumor subtypes
• Accessed human tumor banks to build custom core biopsy arrays, correlated human RNA and protein expression with mechanistic murine studies, and recommended new clinical strategies for specific subtypes of human glioma
• Developed stem cell assays in the laboratory for examination of the role of progenitor cells in the origin of glioma (primary cell harvest from mouse brains, cell line development, tumorsphere formation, flow cytometry) From November 2007 to May 2008 (7 months) Graduate Research Assistant- Cancer Biology @ • Designed Ph.D. project entitled, “Elucidation of the role of Insulin-like Growth Factor Binding Protein-2 (IGFBP-2) in glioma progression using a glial-specific transgenic mouse model.”
• Manager of murine colony (bred, genotyped, and maintained a 2000+ animal colony), trained with Chief of Neuropathology of MD Anderson, Dr. Greg Fuller, in histopathological grading of human and mouse brain tumors, performed preclinical screens of chemotheraputic agents for glioblastoma, and developed many in vitro protocols for protein expression analysis (transfection, viral infection) From August 2003 to December 2007 (4 years 5 months) Undergraduate Research Assistant- Protein Chemistry @ • Analyzed the effect of detergents on peptide resolution using matrix-assisted laser desorption ionization (MALDI), using time-of-flight (TOF) as the main mass analyzer
• Pioneered a joint research project with Dr. Dickson Varner in the College of Veterinary Medicine that analyzed the semen protein content of sub-fertile stallions that have good sperm quality and motility versus the protein content of fertile stallions
• Analyzed the bacterial proteome of E. coli using HPLC and MALDI-TOF MS From January 2000 to May 2003 (3 years 5 months) Undergraduate Research Assistant- Immunology @ • Developed the protocol to generate H2-Oα and H2-Oβ (mouse homologues of DOα and DOβ) His-tagged fusion proteins From May 2002 to August 2002 (4 months) Laboratory Assistant- Virology @ • Research focused on the regulation of viral gene expression and viral RNA packaging using human and simian immunodeficiency viruses (HIV/SIV) and Mason-Pfizer monkey virus (MPMV) as model systems. From May 1997 to August 1999 (2 years 4 months) Welch Summer Scholar- Inorganic Chemistry @ • Developed the protocol to synthesize a chiral ruthenium dimmer, then connect the repeating unit to form a polymer. Inorganic polymers are utilized by pharmaceutical companies to filter contaminants from drugs during large scale manufacturing. From June 1998 to July 1998 (2 months)
Ph.D., Cancer Biology, NeuroOncology, 4.0 @ The University of Texas Health Science Center at Houston From 2003 to 2007 B.S., Genetics @ Texas A&M University From 1999 to 2003 Round Top Carmine High School From 1996 to 1999 Sarah Ph.D. is skilled in: Science, Genetics, Cancer, Research, Molecular Biology, Life Sciences, Experimentation, Cell Biology, Cell Culture, DNA, Cell Based Assays, In Vitro, Protein Chemistry, Breast Cancer, Western Blotting
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