Director of Program Management & Site Operations; Program Director @
Vice President Of Engineering @ Inflammatix, Inc.
Director Of Engineering @ Inflammatix, Inc.
Ph.D., Direct Amplification of Nucleic Acids from Cells @
University of Limerick
I’m a research engineer/scientist with a wide variety of competencies relevant to the biotechnology industry. I’m most comfortable working in a multi-disciplinary environment where I can exploit a range of skills including experimental design and analysis, mechanical design and 3D CAD, molecular biology techniques, software control, prototype fabrication, microfluidic techniques, project management skills and basic electronic and
I’m a research engineer/scientist with a wide variety of competencies relevant to the biotechnology industry. I’m most comfortable working in a multi-disciplinary environment where I can exploit a range of skills including experimental design and analysis, mechanical design and 3D CAD, molecular biology techniques, software control, prototype fabrication, microfluidic techniques, project management skills and basic electronic and optics skills.
My foundation in these areas came from my PhD which involved developing an instrument capable of performing gene expression analysis directly from cells. A period of this work spent in Stokes Bio helped foster the industrious attitude common amongst startup employees. This foundation was then built upon when I became the first PhD level employee at GenCell Biosystems, an exciting biotech startup company. Here, I performed exploratory research into the company’s fledgling technology and am an inventor on the core technology patent. Greater responsibility followed as Chief Scientist providing input across all projects and also as a project lead on a successfully delivered and installed bespoke sample preparation instrument.
I then worked in CRANN on my third biotech platform which was used for the label free detection of various biomarkers, and have a patent pending for the outputs of this work.
Currently, I am working in Accel Biotech as a mechanical engineer across a variety of projects developing instruments for the biotech industry.
Mechanical Engineer @ From October 2014 to Present (1 year 1 month) San Francisco Bay AreaPostdoctoral Researcher @ Joined the NanoBio group to work on the development of nano mechanical bio-sensor arrays for genomics and proteomics.
Core focus of the work centered on employing microfluidic techniques to greatly reduce the sample volume delivered to the bio-sensor. Reducing the sample volume delivered increases the quantity of tests which can be conducted on often precious sample.
Funded as part of a Technology Innovation Development Feasibility (TIDA) Study in collaboration with the Biomedical Diagnostics Institute. From February 2013 to September 2014 (1 year 8 months) DublinChief Scientist @ Project lead for DNA extraction instrument – Led a team of engineers, biologists and software engineers through an aggressive research, development and build schedule for an instrument for the extraction of DNA from seed. Responsibilities also included on-site installation of the instrument and training of appropriate client personnel.
System lead for DNA clean-up subsystem – Led a team of biologists and engineers in the design and development of a subsystem for a sample preparation for sequencing instrument. The subsystem performed addition of core fluids, addition of magnetic beads, magnetic bead clean-up of prepared library, and the pooling of samples in preparation for sequencing.
Major input into the proof of concept and design stages of all instruments was provided as well as the development of instrument testing plans.
Led a team of 5 biologists across a variety of projects – tasks included optimising protocols for use in CLC technology, benchmarking developed instrumentation, exploratory testing with new assays, biology support for all subsystems and instrument development.
A major component of this role was visits and liaising with partners/prospective partners to discuss projects/potential projects. Instrument proposals and proof of concept testing was performed as required. From February 2011 to January 2013 (2 years) Limerick, IrelandSenior R&D Scientist @ Responsibilities included:
The mechanical design of a proof of concept and prototype genotyping instrument. The completed instrument won the New Product Award at SLAS (Society for Laboratory Automation and Screening) 2013.
In house operation of CNC milling machines and training of incumbent staff on machines.
A wide variety of exploratory testing into possible applications of GenCell technology.
Optics testing and liaising with an external optics company for the design of a suitable fluorescence detection system for the genotyping instrument.
Fundamental technology testing and provision of proof of concept results for patent applications. From January 2011 to February 2011 (2 months) Limerick, Ireland
Ph.D., Direct Amplification of Nucleic Acids from Cells @ University of Limerick From 2006 to 2010 Bachelor of Science (with concurrent Teacher Education), Biological Sciences with Physics, 1:1 @ University of Limerick From 2002 to 2006 Paul Fleming is skilled in: Experimentation, Biomedical Engineering, Microfluidics, Molecular Biology, R&D, Labview, DNA extraction, Cell Biology, Cell Culture, DNA sequencing, PCR, Electronics, DNA, Cell, Biotechnology, Genetics, Project Management, Solidworks, 3D CAD, Mechanical design, Science, Biochemistry, Genomics, Physics, LabVIEW, Mechanical Engineering
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