Jamie Bates's Email

I received my PhD in Molecular and Cell Biology in the Immunology department from U.C. Berkeley in Mark S. Schlissel's lab where I studied the role of cis-elements in regulating V(D)J recombination. I was then a postdoctoral fellow in the lab of Patrick O. Brown at Stanford University where I studied posttranscriptional regulation in a murine leukemia model. I am currently a Research Scientist at Gilead Sciences supporting development of small molecule inhibitors in Oncology. Specialties: Molecular Biology, Molecular Immunology, Biochemistry, Cell culture, Mouse work (sterile dissection, FACS analysis, ELISA, transient and stable and miRNA transfection as well as viral transduction of mammalian cells including murine ES cells, transgenics, protein purification, Southern, Western, IP, ChIP, luciferase assays, qRT-PCR, nanostring, luminex, and Incucyte assays) note: I have published under my maiden name (Jamie Kathleen Geier) as well as my married name (Jamie Geier Bates)

Research Scientist II @ Serving as Non-clinical Biology Lead overseeing development of a small molecule inhibitor for oncology that is now in Phase I. Managing a cross functional team of scientists and research associates supporting clinical development. Leading research efforts focusing on indication selection, combinations, and mechanisms of resistance. From January 2015 to Present (1 year) Research Scientist I @ Served as Biology Lead for a small molecule inhibitor in oncology. Led efforts to identify robust pharmicodynamic (PD) biomarkers, understand combination potential in various indications, as well as identify genetic predictors of sensitivity. Ran in vivo models to test efficacy and tolerability. Supervised development of surrogate blood PD assay. Led a cross functional team spanning three sites (Foster City CA, Branford CN, and Seattle WA) and coordinated the activities of these sites in planning, execution, and writing of pharmacology sections of a successful IND. From April 2012 to December 2014 (2 years 9 months) Postdoctoral Fellow @ I used a leukemia model to study translational regulation. I employed a recently developed genome-wide translation assay to measure translational regulation upon reversal of transformation induced by the small molecule imatinib. I initiated collaborations with mass spectrometry experts at the Fred Hutch Cancer Research Center to analyze the contribution of translational regulation to protein production. We found that the regulation of translation contributes considerably to shaping the cancerous cells' proteome, in particular genes encoding proteins involved in mediating adhesion interactions (PLoS One. 2012;7(5):e37108). From January 2007 to March 2012 (5 years 3 months) Graduate Student @ I received my PhD for studying the regulation of V(D)J recombination In Mark Schlissel's lab in the Immunology department of U.C. Berkeley’s Molecular and Cell Biology program. The RAG (recombination activating genes) direct recombination of Ig loci in a temporally, spatially, and cell-type-specific manner. Only particular loci are subject to RAG-mediated cleavage during a defined stage of development. I showed that the chromosomal position of a knocked-in V gene affected the timing, cell-type specificity, and order of its rearrangement (J Exp Med. 2007; 204:3247-56). We hypothesized that this was a result of being placed on the opposite side of an insulating element, which was subsequently proven to be the case. We tested this hypothesis by knocking out a DNAse-hypersenstiive site I identified, marked by particular histone modifications, while another group knocked out another site adjacent to this hypersensitive site. Their knockout had a profound effect on VDJ recombination while ours, only a few Kb away, had no effect. Thus the insulating element we hypothesized existed did indeed exist (Nature. 2011; 477:424-30). From September 1999 to May 2006 (6 years 9 months)

Ph.D., Biochemistry, Immunology @ University of California, Berkeley From 1999 to 2006 Barnard College From 1994 to 1999 Jamie Bates is skilled in: Cell, Cell Culture, Molecular Biology, ELISA, Transfection, qPCR, Cell Biology, Biochemistry, Genetics, Assay Development