Senior Director, Genomics Research Center @ AbbVie
Director, Target Enabling Science and Technologies @ AbbVie
Accomplished scientist and leader in biopharmaceutical R&D. Passionate about innovation and opportunities to transform drug discovery and development. Experienced and successful alliance manager. Highly effective communicator and integrator. Track record of working across organizational boundaries. Leader with focus on integrity, collaboration and developing people. Broad understanding of technologies in drug discovery and Translational Research. Knowledgeable about drug
Accomplished scientist and leader in biopharmaceutical R&D. Passionate about innovation and opportunities to transform drug discovery and development. Experienced and successful alliance manager. Highly effective communicator and integrator. Track record of working across organizational boundaries. Leader with focus on integrity, collaboration and developing people. Broad understanding of technologies in drug discovery and Translational Research. Knowledgeable about drug discovery and exploratory biology in multiple disease areas.
Director, Target Enabling Science and Technology @ From September 2014 to Present (1 year 4 months) Group Director, Applied Genomics @ Responsible for Genomic and Proteomic Sciences Group. Oversees the development and application of genomic and proteomic technologies in support of all BMS Disease Research Areas with major focuses on target identification, target validation, biomarker discovery and characterization of early stage compounds and clinical candidates. Key technology platforms include Genetic Screening, Chemogenomics, High Content Cellular Assays, mRNA profiling, DNA Sequencing, in vivo RNAi and ASOs, transgenic mouse creation, Mouse Genotyping and Protein Analytical Sciences. Strategic leader for Applied Genomics Department. Leadership roles in various strategic initiatives including chemogenomics and phenotypic screening, stem cell-derived models and multiple technology strategies within and outside of genomics. Also responsible for multiple external alliances for creation and characterization of genetically modified animals and for in vivo delivery of siRNAs. Viral delivery systems. Primary human cells and IPSC-derived cellular assays. From 2008 to May 2014 (6 years) Director, Functional Genomics @ Responsible for Mammalian Target Validation Group. Major focuses on in vitro and in vivo RNAi, High Content Screening, phenotypic screens, chemogenomics, creation and analysis of genetically modified animals. Collaborations with multiple Disease Areas. From 2006 to 2008 (2 years) Associate Director, Applied Genomics @ Led teams focused on target identification and validation in support of multiple Wyeth Discovery Research Areas. Major emphasis on siRNA library-based phenotypic screens, viral expression systems, High Content Screening, creation of genetically modified animals and functional analysis of BMPs. From 2000 to 2006 (6 years) Principal Research Scientist @ Led team in assay development and gene discovery for pancreatic islet stem cell growth and differentiation. Coordinated functional testing in cell based assays and over-expression in transgenic mice. Established cDNA microarray technology and led one of earliest known efforts to perform mRNA expression profiling to study pancreas development. From 1995 to 2000 (5 years) Post-doctoral Research Fellow, Instructor in Medicine @ Studied signal transduction and transcriptional regulation of pancreatic islet hormone genes. Cloned the cDNA and gene promoter for IDX-1/PDX-1, an important regulator of pancreas development and islet hormone gene expression. Characterized protein functional domains and mRNA expression levels. Created mis-expression transgenic mice to study function in vivo. From 1990 to 1994 (4 years)
Ph.D., Pharmacology @ Michigan State University From 1985 to 1990 Christopher Miller is skilled in: Assay Development, Genomics, In Vivo, Genetics, Pharmacology, DNA, Biotechnology, Biomarker Discovery, Translational Research, DNA sequencing, Biomarkers, Lifesciences, RNAi, Toxicology, Drug Discovery
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