Carlo Pergola's Email

I’m a highly motivated scientist with multidisciplinary experience in Pharmaceutical Sciences, for small molecules and biologics. I'm inspired by working to improve global health. I have excellent interpersonal, managerial and communication skills in different languages (English, Italian, German), with positive personality, propensity to teamwork and a natural scientific curiosity.

Laboratory Head @ Vaccine Chemistry and Formulation. Leading the Formulation Science Laboratory, responsible for formulation design, optimization and preparation of complex multicomponent vaccines (composed by different antigens -including proteins, glycoconjugates, and RNA - and different adjuvants - including emulsions, inorganic compounds, and nanoparticles), their preclinical evaluation and related stability studies. From March 2015 to Present (10 months) Siena Area, ItalyLaboratory Head @ Vaccine Chemistry and Formulation Function. Leading the Formulation Science Laboratory, responsible for the support to vaccine research programs from antigen discovery, through preclinical evaluation, pre-formulation analyses, and formulation design up to product optimization for Technical Development Decision Point, including vaccine stability evaluation and analytical characterization. Accountable for development of novel delivery systems, characterization of antigen-adjuvant interactions and for laboratory automation. From February 2014 to February 2015 (1 year 1 month) Siena Area, ItalyGroup Leader @ Leading Research projects in the field of inflammation, immunity and cancer, as regard to basic biological and pharmacological research, pre-clinical discovery and characterization of lead synthetic and natural compounds, target ID and validation, development of analytical methods. Partecipation to national ad international research projects financed after peer review-based competitions, responsible for collection and interpretation of the results, preparation of reports and data presentation at national and international congresses. Projectleader for biological security and genetical engineering and responsible for the auditing. Leading analytical method validation for industrial partners. Methods: cell culture (immune and cancer cells), analysis of human blood cells and serum; ELISA, SDS-PAGE, 2D-DIGE, Western Blot, fluorescent microscopy, molecular biology, analytics (HPLC, UPLC-MS/MS), lipidomics, DARTS, target-fishing, in vivo models of inflammation. Teaching and coordination activities: • Responsible and coordinator of the practical course in ”Drug Analytics” (6. Sem): • Supervisor and coordinator of undergraduate students during their experimental thesis and practical course in Pharmaceutical Chemistry; • Lecturer at the seminars in “Cellular Pharmacology”; Master in Biochemistry; • Lecturer at the course of “Pharmaceutical and Medicinal Chemistry: structure, activity, reactivity, pharmacological relevance, analytics and synthesis of drugs”; • Lecturer at the seminars in “Molecular Pharmacology”, Master in Molecular Medicine; • Tranfer of technology (planning and setting of the S1-laboratories, HPLC, LC-MS/MS, electrophoresis, molecular biology, UV/Vis spectroscopy) from University Tuebingen to University Jena; establishment of a fluorescent microscopy facility. From August 2010 to January 2014 (3 years 6 months) Postdoctoral fellow @ Responsible for Research project on gender differences in inflammation. Performing identification and optimization of lead compounds inhibiting inflammatory enzymes. Teaching in the practical course ”Instrumental Pharmaceutical Analytics, Chromatography and Spectroscopy” for undergraduated students. Co-supervisor of undergraduate students during the practical course in Instrumental Analytics and supervisor of undergraduate students during their Experimental Thesis. From June 2008 to July 2010 (2 years 2 months) Scientist @ Performing Research on gender differences in the activity of inflammatory enzymes (e.g., COX, LOs). Development of analytical assays for analysis of inflammatory mediators. From December 2007 to May 2008 (6 months)

Education in scientific management and people leadership (DFG-FOR1406) @ University Jena From 2010 to 2013 Education in “Security in genetical engineering” @ University Heidelberg (Germany) From 2011 to 2011 Doctor of Philosophy (PhD), Pharmaceutical Sciences, First in his class. @ University of Naples “Federico II” (Italy) and Eberhard-Karls-University, Tübingen (Germany) From 2004 to 2007 Approbation as Pharmacist @ University of Naples “Federico II” (Naples, Italy)Degree (MD), Pharmaceutical Chemistry and Technology, 110 cum Laude/110 @ University of Naples "Federico II", Naples, Italy From 1999 to 2004 High School Diploma, 100/100 @ Liceo Classico J. Sannazaro From 1994 to 1999 Carlo Pergola is skilled in: Research, Pharmacology, Medicinal Chemistry, Natural Products, Inflammation, Immunology, Cancer, Molecular Biology, Cell Culture, Cellular Communications, Cell Signaling, Cytotoxicity, Cytokines, Chemokines, target validation